Isabelle LURON, DR
Skills
• Nutritional programming• Nutrition
• Gut physiology
• Microbiota-host crosstalk
Research topics and scientific objectives
• Understand the impact of early nutrition (maternal diet and infant formula composition) on gut physiology and consequences in adults facing an adverse nutritional environment• Decipher the importance of early bacterial colonization on intestinal homeostasis later in life and relationship with glucose metabolism
Education and main positions held
Current projects
CLIMAPIG : Research collaborative project with the industry – Impact of infant formula composition on gut digestion and physiology and glucose metabolism using the mini-pig as model for human infant and adult.FOSGUT : Research collaborative project with the industry – Impact of fructooligosaccahrides on intestinal physiology and glucose metabolism using the pig as model for human infant and adult.
EPIPIG : Research collaborative project with the industry – Importance of early bacterial colonization on further sensitivity to digestive disorders
HED-O-SHIFT : Identification of intestinal phenotypes correlated with neuro-behavioral patterns in obese mini-pigs undergoing laparoscopic Roux-en-Y gastric bypass
Selected publications
Infant formula interface and fat source impact on neonatal digestion and gut microbiota.Bourlieu C, Bouzerzour K, Ferret-Bernard S, Le Bourgot C, Chever S, Ménard O, Deglaire A, Cuinet I, Le Ruyet P, Bonhomme C, Dupont D and Le Huërou-Luron IEuropean Journal of Lipid Sciences and Technology 117, in press
Maternal short-chain fructooligosaccharide supplementation influences intestinal immune system maturation in piglets. Le Bourgot C, Ferret-Bernard S, Le Normand L, Savary G, Menendez-Aparicio E, Blat S, Appert-Bossard E, Respondek F, Le Huërou-Luron I Plos One, 9:e107508
Dietary protein excess during neonatal life alters colonic microbiota and mucosal response to inflammatory mediators later in life in female pigs. Boudry G, Jamin A, Chatelais L, Gras-Le Guen C, Michel C, Le Huërou-Luron IJournal of Nutrition, 143: 1225-1232
Maternal 18:3n-3 favors piglet intestinal passage of LPS and promotes intestinal anti-inflammatory response to this bacterial ligand.Desaldeleer C, Ferret-Bernard S, de Quelen F, Le Normand L, Perrier C, Savary G, Romé V, Michel C, Mourot J, Le Huërou-Luron I, Boudry GJournal of Nutritional Biochemistry, 25 : 1090-1098.
5 Intrauterine growth restriction modifies the developmental pattern of intestinal structure, transcriptomic profile and bacterial colonization in neonatal pigs. D'inca R, Kloareg M, Gras-Le Guen C, Le Huërou-Luron I Journal of Nutrition 140: 925-931
