Nicolas COQUERY, IR
Skills
Brain Imaging, fNIRS, fMRI, rsMRI. Behavior. Multidisciplinary approaches.http://www.researchgate.net/profile/Nicolas_Coquery
Research topics and scientific objectives
Impact of nutrition on brain functions with in vivo imagingEducation and main positions held
EDUCATION2011/2012 Authorization for animal handling (Niv. II) and surgery
2004-2009 Medical Neuroscience PhD Program, Humboldt University, PhD student in the Laboratory for Molecular Psychiatry, Clinic for Psychiatry and Psychotherapy, Charite-Mitte, Berlin - Germany
2002-2004 ESIL-Biotechnology, Engineering School in Biotechnology. University of Aix Marseille II - France
1997-2002 Master’s Degree of Cell Biology and Physiology. University of Paris XI - France
PROFESSIONAL EXPERIENCE
From 2013 Research associate (IR), INRA, Food and Digestive, Nervous and Behavioural Adaptations Unit (UR ADNC), St-Gilles, France
2008-2013 Postdoctoral Fellow, Functionnal and Metabolic Neuroimaging Laboratory of the Grenoble Institute of Neuroscience GIN – U836 - INSERM, France
Systemic and local therapy against Glioblastoma, special focus on imaging.
Radiotherapy. Radiosensitizing, Multiparametric MRI measurements. Ex vivo imaging: macroscopy, 2 photons. Murine and human glioblastoma model (F98, C6, RG2, U87). Stereotactic surgery. Convection-enhanced delivery (CED). MRI acquisition and processing. Stem cell in vivo tracking: bioluminescence, fluorescence.
2004-2008 Medical Neuroscience PhD Program, Humboldt University, PhD student in the Laboratory for Molecular Psychiatry, Clinic for Psychiatry and Psychotherapy, Charite-Mitte, Berlin - Germany
PhD Thesis: Hippocampal mesenchymal stem cells transplantation in rat model of depression
Culturing MSC, lentiviral transduction, labelling with superparamagnetic agent (VSOP). MRI in vivo cell tracking (7T) and analysis (ImageJ, Amira). Immunohistochemistry (neurogenesis). Animal handling and stereotactic operative procedure. Models of depression in rodent: Learned Helplessness, Modified Forced Swim Test.
Current projects
Involved in all projects of Team NGB related to human neuroimagingSelected publications
The three glioma rat models C6, F98 and RG2 exhibit different metabolic profiles: in vivo 1 H MRS and ex vivo 1 H HRMAS combined with multivariate statistics. Coquery N, Stupar V, FarionR, Maunoir-Regimbal S, Barbier EL, Remy C, Fauvelle F.Metabomics. 2015. Epub
Microvascular MRI and unsupervised clustering yields histology-resembling images in two rat models of glioma. Coquery N, Francois O, Lemasson B, Debacker C, Farion R, Rémy C, Barbier EL.J Cereb Blood Flow Metab. 2014 Aug;34(8):1354-62. doi: 10.1038/jcbfm.2014.90. Epub 2014 May 21. PubMed PMID: 24849664; PubMed Central PMCID: PMC4126096.
Intrahippocampal transplantation of mesenchymal stromal cells promotes neuroplasticity.Coquery N, Blesch A, Stroh A, Fernández-Klett F, Klein J, Winter C, Priller J.Cytotherapy. 2012 Oct;14(9):1041-53. doi: 10.3109/14653249.2012.694418. Epub 2012 Jul 5. PubMed PMID: 22762522
Distribution and radiosensitizing effect of cholesterol-coupled Dbait molecule in rat model of glioblastoma.Coquery N, Pannetier N, Farion R, Herbette A, Azurmendi L, Clarencon D, Bauge S, Josserand V, Rome C, Coll JL, Sun JS, Barbier EL, Dutreix M, Remy CCPLoS One. 2012;7(7):e40567. doi: 10.1371/journal.pone.0040567. Epub 2012 Jul 17. PubMed PMID: 22815765; PubMed Central PMCID: PMC3398898.
Administration of interferon-alpha in mice provokes peripheral and central modulation of immune cells, accompanied by behavioral effects. Orsal AS, Blois SM, Bermpohl D, Schaefer M, Coquery N.Neuropsychobiology. 2008;58(3-4):211-22. doi: 10.1159/000201718. Epub 2009 Feb 12. PubMed PMID: 19212136.
